Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Finerenone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. Finerenone together with olmesartan also increases hyperkalemia risk, while hydrochlorothiazide partly offsets it.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by amlodipine raises finerenone levels, and finerenone and olmesartan both increase serum potassium.
What to do
Monitor serum potassium and renal function at initiation and after dose changes, and adjust finerenone dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Finerenone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. Finerenone together with olmesartan also increases hyperkalemia risk, while hydrochlorothiazide partly offsets it.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes, and adjust finerenone dose per labeling.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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