Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Hydrochlorothiazide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so giving separate hydrochlorothiazide duplicates therapy. This increases the risk of volume depletion, hypotension, hypokalemia, hyponatremia, hyperuricemia and hyperglycemia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication leads to additive inhibition of the sodium-chloride cotransporter in the distal tubule.
What to do
Avoid giving additional hydrochlorothiazide with the combination product and review the regimen for duplication. If unavoidable, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so giving separate hydrochlorothiazide duplicates therapy. This increases the risk of volume depletion, hypotension, hypokalemia, hyponatremia, hyperuricemia and hyperglycemia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving additional hydrochlorothiazide with the combination product and review the regimen for duplication. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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