Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Temsirolimus
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Use of mTOR inhibitors with calcium channel blockers has been associated with an increased incidence of angioedema. In addition, temsirolimus can cause hyperglycemia and hyperlipidemia, which thiazides may worsen.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
The mechanism is not well established; reduced bradykinin breakdown or altered vascular permeability has been proposed.
What to do
Counsel patients to report swelling of the face, lips or tongue and stop the offending agent if angioedema occurs. Monitor glucose and lipids during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Temsirolimus?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Use of mTOR inhibitors with calcium channel blockers has been associated with an increased incidence of angioedema. In addition, temsirolimus can cause hyperglycemia and hyperlipidemia, which thiazides may worsen.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips or tongue and stop the offending agent if angioedema occurs. Monitor glucose and lipids during therapy.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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