Drug interactions
Amlodipine-perindopril + Azathioprine
Severity: Moderate
Amlodipine-perindopril and Azathioprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors given with azathioprine have been associated with anemia and leukopenia or neutropenia, particularly in renal impairment. The bone marrow suppression can be clinically significant.
What this interaction means in plain words
Amlodipine-perindopril and Azathioprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Azathioprine belongs to Gastrointestinal Tract.
Why it happens
ACE inhibitors may reduce erythropoietin and impair bone marrow response, adding to azathioprine myelosuppression; mechanism not fully established.
What to do
Monitor complete blood counts regularly, especially at initiation and in renal impairment, and reduce azathioprine if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Azathioprine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Azathioprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors given with azathioprine have been associated with anemia and leukopenia or neutropenia, particularly in renal impairment. The bone marrow suppression can be clinically significant.
How serious is the interaction between Amlodipine-perindopril and Azathioprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, especially at initiation and in renal impairment, and reduce azathioprine if cytopenias develop.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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