Drug interactions
Amlodipine-perindopril + Celecoxib
Severity: Moderate
Amlodipine-perindopril and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can reduce the antihypertensive effect of perindopril and amlodipine and can impair kidney function when combined with an ACE inhibitor. Risk is higher in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Amlodipine-perindopril and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Inhibition of COX-2 reduces renal vasodilatory prostaglandins, causing sodium retention and lower glomerular filtration that opposes ACE inhibitor action.
What to do
Use the lowest effective celecoxib dose for the shortest time, or choose paracetamol. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Celecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Amlodipine-perindopril with Celecoxib?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can reduce the antihypertensive effect of perindopril and amlodipine and can impair kidney function when combined with an ACE inhibitor. Risk is higher in older, dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-perindopril and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective celecoxib dose for the shortest time, or choose paracetamol. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
