Drug interactions
Amlodipine-perindopril + Chloramphenicol
Severity: Minor
Amlodipine-perindopril and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise amlodipine exposure, potentially causing hypotension and peripheral edema. The effect is predicted and modest, and chloramphenicol is rarely used systemically.
What this interaction means in plain words
Amlodipine-perindopril and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of amlodipine.
What to do
Monitor blood pressure and for edema or dizziness during combined use. Reduce amlodipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amlodipine-perindopril with Chloramphenicol?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may inhibit CYP3A4 and raise amlodipine exposure, potentially causing hypotension and peripheral edema. The effect is predicted and modest, and chloramphenicol is rarely used systemically.
How serious is the interaction between Amlodipine-perindopril and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during combined use. Reduce amlodipine dose if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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