Drug interactions
Amlodipine-perindopril + Cisatracurium
Severity: Moderate
Amlodipine-perindopril and Cisatracurium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may potentiate the neuromuscular blockade of cisatracurium, prolonging its effect. The clinical effect is generally modest but relevant during anesthesia.
What this interaction means in plain words
Amlodipine-perindopril and Cisatracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Cisatracurium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, adding to nondepolarizing neuromuscular blockade.
What to do
Monitor neuromuscular blockade with train-of-four stimulation and adjust cisatracurium dosing accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Cisatracurium
Frequently asked questions
Can I take Amlodipine-perindopril with Cisatracurium?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Cisatracurium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers may potentiate the neuromuscular blockade of cisatracurium, prolonging its effect. The clinical effect is generally modest but relevant during anesthesia.
How serious is the interaction between Amlodipine-perindopril and Cisatracurium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four stimulation and adjust cisatracurium dosing accordingly.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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