Drug interactions
Amlodipine-perindopril + Diclofenac
Severity: Moderate
Amlodipine-perindopril and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can blunt the blood pressure lowering effect of perindopril and amlodipine. Combined with an ACE inhibitor it can cause acute kidney injury, especially in older or volume-depleted patients.
What this interaction means in plain words
Amlodipine-perindopril and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces renal blood flow and promotes sodium and water retention, opposing ACE inhibitor effects.
What to do
Use the lowest NSAID dose for the shortest time or choose paracetamol. Monitor blood pressure, creatinine and potassium and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Amlodipine-perindopril with Diclofenac?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can blunt the blood pressure lowering effect of perindopril and amlodipine. Combined with an ACE inhibitor it can cause acute kidney injury, especially in older or volume-depleted patients.
How serious is the interaction between Amlodipine-perindopril and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time or choose paracetamol. Monitor blood pressure, creatinine and potassium and ensure adequate hydration.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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