Drug interactions
Amlodipine-perindopril + Felodipine
Severity: Moderate
Amlodipine-perindopril and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and felodipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds to vasodilatory adverse effects such as hypotension, edema and flushing without meaningful benefit.
What this interaction means in plain words
Amlodipine-perindopril and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade in vascular smooth muscle.
What to do
Avoid using two dihydropyridines together; use a single agent and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Amlodipine-perindopril with Felodipine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and felodipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds to vasodilatory adverse effects such as hypotension, edema and flushing without meaningful benefit.
How serious is the interaction between Amlodipine-perindopril and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridines together; use a single agent and adjust the dose.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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