Drug interactions
Amlodipine-perindopril + Mitotane
Severity: Moderate
Amlodipine-perindopril and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can markedly lower amlodipine levels. Blood pressure control may be lost, and the effect can persist long after mitotane is stopped.
What this interaction means in plain words
Amlodipine-perindopril and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure and increase the amlodipine dose if needed. Reassess when mitotane is stopped, as induction wanes slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Amlodipine-perindopril with Mitotane?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can markedly lower amlodipine levels. Blood pressure control may be lost, and the effect can persist long after mitotane is stopped.
How serious is the interaction between Amlodipine-perindopril and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the amlodipine dose if needed. Reassess when mitotane is stopped, as induction wanes slowly.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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