Drug interactions
Amlodipine-perindopril + Nadolol
Severity: Moderate
Amlodipine-perindopril and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol with amlodipine and perindopril gives additive blood-pressure reduction and may cause bradycardia or hypotension. Dihydropyridines such as amlodipine are generally well tolerated with beta-blockers, so the combination is usually manageable.
What this interaction means in plain words
Amlodipine-perindopril and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of beta-blockade, vasodilation and ACE inhibition.
What to do
Monitor blood pressure and heart rate during initiation and dose changes. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Nadolol
Frequently asked questions
Can I take Amlodipine-perindopril with Nadolol?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol with amlodipine and perindopril gives additive blood-pressure reduction and may cause bradycardia or hypotension. Dihydropyridines such as amlodipine are generally well tolerated with beta-blockers, so the combination is usually manageable.
How serious is the interaction between Amlodipine-perindopril and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and dose changes. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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