Drug interactions
Amlodipine-perindopril + Nicardipine
Severity: Moderate
Amlodipine-perindopril and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amlodipine and nicardipine are dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds to vasodilatory adverse effects such as hypotension, edema and tachycardia. There is little added benefit from using two agents of the same class.
What this interaction means in plain words
Amlodipine-perindopril and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade causing vasodilation.
What to do
Avoid duplicate dihydropyridine therapy; use a single agent and adjust its dose. If both are temporarily used, monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-perindopril with Nicardipine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amlodipine and nicardipine are dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds to vasodilatory adverse effects such as hypotension, edema and tachycardia. There is little added benefit from using two agents of the same class.
How serious is the interaction between Amlodipine-perindopril and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate dihydropyridine therapy; use a single agent and adjust its dose. If both are temporarily used, monitor blood pressure closely.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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