Drug interactions
Amlodipine-perindopril + Probenecid
Severity: Minor
Amlodipine-perindopril and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal organic anion transport and may reduce the tubular secretion of perindoprilat, the active metabolite. Exposure to perindopril could rise modestly, with greater blood pressure lowering.
What this interaction means in plain words
Amlodipine-perindopril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibition of renal tubular secretion of perindoprilat.
What to do
Monitor blood pressure and renal function when probenecid is started; reduce perindopril dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Amlodipine-perindopril with Probenecid?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid inhibits renal organic anion transport and may reduce the tubular secretion of perindoprilat, the active metabolite. Exposure to perindopril could rise modestly, with greater blood pressure lowering.
How serious is the interaction between Amlodipine-perindopril and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when probenecid is started; reduce perindopril dose if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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