Drug interactions
Amlodipine-perindopril + Rifapentine
Severity: Moderate
Amlodipine-perindopril and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and may reduce amlodipine concentrations, leading to weaker blood pressure control. The effect is somewhat less than with rifampin but can still be relevant.
What this interaction means in plain words
Amlodipine-perindopril and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces hepatic and intestinal CYP3A4, accelerating amlodipine metabolism.
What to do
Monitor blood pressure during rifapentine therapy and titrate amlodipine upward if needed. Re-adjust the dose after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Rifapentine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and may reduce amlodipine concentrations, leading to weaker blood pressure control. The effect is somewhat less than with rifampin but can still be relevant.
How serious is the interaction between Amlodipine-perindopril and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during rifapentine therapy and titrate amlodipine upward if needed. Re-adjust the dose after rifapentine is stopped.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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