Drug interactions
Amlodipine-perindopril + Thioridazine
Severity: Moderate
Amlodipine-perindopril and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine can cause orthostatic hypotension through alpha-blockade, adding to antihypertensive effect. It also prolongs the QT interval, which matters if the patient develops electrolyte disturbances or hypotension-related complications.
What this interaction means in plain words
Amlodipine-perindopril and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade by thioridazine.
What to do
Monitor blood pressure and orthostatic symptoms and check potassium and ECG as appropriate; reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Thioridazine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine can cause orthostatic hypotension through alpha-blockade, adding to antihypertensive effect. It also prolongs the QT interval, which matters if the patient develops electrolyte disturbances or hypotension-related complications.
How serious is the interaction between Amlodipine-perindopril and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms and check potassium and ECG as appropriate; reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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