Drug interactions
Amlodipine-perindopril + Treprostinil
Severity: Moderate
Amlodipine-perindopril and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with antihypertensives can increase the risk of symptomatic hypotension.
What this interaction means in plain words
Amlodipine-perindopril and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation from prostacyclin receptor agonism and calcium channel blockade.
What to do
Monitor blood pressure when starting or titrating treprostinil and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Amlodipine-perindopril with Treprostinil?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with antihypertensives can increase the risk of symptomatic hypotension.
How serious is the interaction between Amlodipine-perindopril and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or titrating treprostinil and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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