Drug interactions
Amlodipine-perindopril + Verapamil
Severity: Moderate
Amlodipine-perindopril and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil and amlodipine are both calcium channel blockers, so combining them adds vasodilation and may cause hypotension and edema. Verapamil also inhibits CYP3A4 and may raise amlodipine exposure, and its cardiac effects add bradycardia or conduction risk with other agents.
What this interaction means in plain words
Amlodipine-perindopril and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade with verapamil inhibition of CYP3A4 and P-glycoprotein.
What to do
Avoid duplicate calcium channel blocker therapy where possible; if combined, monitor blood pressure, heart rate and edema and adjust the amlodipine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Amlodipine-perindopril with Verapamil?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil and amlodipine are both calcium channel blockers, so combining them adds vasodilation and may cause hypotension and edema. Verapamil also inhibits CYP3A4 and may raise amlodipine exposure, and its cardiac effects add bradycardia or conduction risk with other agents.
How serious is the interaction between Amlodipine-perindopril and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate calcium channel blocker therapy where possible; if combined, monitor blood pressure, heart rate and edema and adjust the amlodipine dose.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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