Drug interactions
Amlodipine-perindopril + Voclosporin
Severity: Moderate
Amlodipine-perindopril and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia, reduced glomerular filtration and nephrotoxicity, all of which can be worsened by an ACE inhibitor. This raises the risk of hyperkalemia and acute kidney injury, particularly in patients with lupus nephritis and reduced renal function.
What this interaction means in plain words
Amlodipine-perindopril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on potassium retention and on renal hemodynamics (afferent vasoconstriction by calcineurin inhibitor and efferent dilation by ACE inhibitor).
What to do
Monitor serum potassium, creatinine and eGFR regularly, particularly after starting or changing doses, and reduce or interrupt voclosporin per label if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Voclosporin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia, reduced glomerular filtration and nephrotoxicity, all of which can be worsened by an ACE inhibitor. This raises the risk of hyperkalemia and acute kidney injury, particularly in patients with lupus nephritis and reduced renal function.
How serious is the interaction between Amlodipine-perindopril and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and eGFR regularly, particularly after starting or changing doses, and reduce or interrupt voclosporin per label if renal function declines.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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