Drug interactions
Amlodipine-perindopril + Voxelotor
Severity: Moderate
Amlodipine-perindopril and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise amlodipine concentrations. This may enhance vasodilation, causing hypotension and peripheral edema.
What this interaction means in plain words
Amlodipine-perindopril and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and edema and reduce the amlodipine dose if hypotension or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Amlodipine-perindopril with Voxelotor?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may raise amlodipine concentrations. This may enhance vasodilation, causing hypotension and peripheral edema.
How serious is the interaction between Amlodipine-perindopril and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and reduce the amlodipine dose if hypotension or symptoms occur.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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