Drug interactions
Amobarbital + Aprepitant
Severity: Moderate
Amobarbital and Aprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are CYP3A4 inducers and can lower aprepitant concentrations, potentially reducing its antiemetic efficacy. Amobarbital also adds sedation.
What this interaction means in plain words
Amobarbital and Aprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Amobarbital induces CYP3A4, increasing aprepitant metabolism.
What to do
Avoid the combination where possible, or monitor for breakthrough nausea and vomiting and consider additional antiemetics. Watch for additive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Aprepitant?
MediHelp rates the interaction as moderate. Amobarbital and Aprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are CYP3A4 inducers and can lower aprepitant concentrations, potentially reducing its antiemetic efficacy. Amobarbital also adds sedation.
How serious is the interaction between Amobarbital and Aprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor for breakthrough nausea and vomiting and consider additional antiemetics. Watch for additive sedation.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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