Drug interactions
Amobarbital + Colchicine
Severity: Moderate
Amobarbital and Colchicine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer that may speed colchicine metabolism and lower its levels. This could reduce efficacy in gout flare treatment or prophylaxis and in familial Mediterranean fever.
What this interaction means in plain words
Amobarbital and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Colchicine belongs to Genitourinary.
Why it happens
Induction of CYP3A4 and possibly P-glycoprotein by amobarbital increases colchicine clearance.
What to do
Monitor clinical response to colchicine and adjust the dose if control is inadequate. Reassess dosing when the barbiturate is stopped to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Colchicine?
MediHelp rates the interaction as moderate. Amobarbital and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is an enzyme inducer that may speed colchicine metabolism and lower its levels. This could reduce efficacy in gout flare treatment or prophylaxis and in familial Mediterranean fever.
How serious is the interaction between Amobarbital and Colchicine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to colchicine and adjust the dose if control is inadequate. Reassess dosing when the barbiturate is stopped to avoid toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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