Drug interactions
Amobarbital + Dantrolene
Severity: Moderate
Amobarbital and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital adds to the sedative effect of dantrolene and, as a CYP3A4 inducer, may lower dantrolene exposure. The result can be excessive sedation together with reduced muscle relaxant effect.
What this interaction means in plain words
Amobarbital and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression plus barbiturate induction of CYP3A4-mediated dantrolene metabolism.
What to do
Monitor sedation and respiratory status and assess spasticity response. Adjust the dantrolene dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Dantrolene?
MediHelp rates the interaction as moderate. Amobarbital and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital adds to the sedative effect of dantrolene and, as a CYP3A4 inducer, may lower dantrolene exposure. The result can be excessive sedation together with reduced muscle relaxant effect.
How serious is the interaction between Amobarbital and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status and assess spasticity response. Adjust the dantrolene dose if efficacy declines.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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