Drug interactions
Amobarbital + Duloxetine
Severity: Moderate
Amobarbital and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce duloxetine concentrations through enzyme induction, potentially weakening antidepressant or analgesic effect. Additive CNS depression is also possible. The pharmacokinetic effect is likely modest and manageable.
What this interaction means in plain words
Amobarbital and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Induction of hepatic CYP1A2 (and possibly CYP2D6) by amobarbital increases duloxetine metabolism, along with additive sedation.
What to do
Monitor for reduced duloxetine response and excess sedation; adjust the duloxetine dose according to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Amobarbital with Duloxetine?
MediHelp rates the interaction as moderate. Amobarbital and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce duloxetine concentrations through enzyme induction, potentially weakening antidepressant or analgesic effect. Additive CNS depression is also possible. The pharmacokinetic effect is likely modest and manageable.
How serious is the interaction between Amobarbital and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced duloxetine response and excess sedation; adjust the duloxetine dose according to clinical effect.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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