Drug interactions
Amobarbital + Ergotamine
Severity: Moderate
Amobarbital and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may lower ergotamine levels and reduce its antimigraine effect. Barbiturates also add sedation, and the clinical significance is mainly reduced efficacy rather than toxicity.
What this interaction means in plain words
Amobarbital and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by amobarbital increases the first-pass and systemic metabolism of ergotamine.
What to do
Monitor for reduced migraine relief; consider another migraine therapy if ergotamine becomes ineffective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Amobarbital with Ergotamine?
MediHelp rates the interaction as moderate. Amobarbital and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may lower ergotamine levels and reduce its antimigraine effect. Barbiturates also add sedation, and the clinical significance is mainly reduced efficacy rather than toxicity.
How serious is the interaction between Amobarbital and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine relief; consider another migraine therapy if ergotamine becomes ineffective.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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