Drug interactions
Amobarbital + Esomeprazole
Severity: Moderate
Amobarbital and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may speed up the clearance of esomeprazole, lowering its exposure. Acid suppression may be weaker than expected, which matters in patients treated for GERD, ulcers or H. pylori eradication.
What this interaction means in plain words
Amobarbital and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Amobarbital induces CYP2C19 and CYP3A4, the main enzymes that metabolize esomeprazole.
What to do
Monitor for reduced symptom control and consider a higher esomeprazole dose if the response is inadequate. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Esomeprazole?
MediHelp rates the interaction as moderate. Amobarbital and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and may speed up the clearance of esomeprazole, lowering its exposure. Acid suppression may be weaker than expected, which matters in patients treated for GERD, ulcers or H. pylori eradication.
How serious is the interaction between Amobarbital and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and consider a higher esomeprazole dose if the response is inadequate. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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