Drug interactions
Amobarbital + Fenfluramine
Severity: Moderate
Amobarbital and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine used for seizure disorders can cause somnolence, and its effects with a barbiturate are not well characterized. Additive sedation is possible, while fenfluramine's stimulant properties may partly oppose it.
What this interaction means in plain words
Amobarbital and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic CNS effects; barbiturate CYP induction may also lower fenfluramine exposure.
What to do
Monitor for sedation and for changes in seizure control, and adjust doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Amobarbital with Fenfluramine?
MediHelp rates the interaction as moderate. Amobarbital and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine used for seizure disorders can cause somnolence, and its effects with a barbiturate are not well characterized. Additive sedation is possible, while fenfluramine's stimulant properties may partly oppose it.
How serious is the interaction between Amobarbital and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for changes in seizure control, and adjust doses based on response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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