Drug interactions
Amobarbital + Fluconazole
Severity: Minor
Amobarbital and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may lower fluconazole concentrations, potentially reducing antifungal effect. The effect is likely modest because fluconazole is mostly excreted unchanged by the kidneys.
What this interaction means in plain words
Amobarbital and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Barbiturate enzyme induction may modestly increase fluconazole clearance; fluconazole in turn may increase barbiturate levels via CYP2C19 inhibition.
What to do
Monitor antifungal response and barbiturate sedation. Adjust fluconazole dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Fluconazole?
MediHelp rates the interaction as minor. Amobarbital and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates are enzyme inducers and may lower fluconazole concentrations, potentially reducing antifungal effect. The effect is likely modest because fluconazole is mostly excreted unchanged by the kidneys.
How serious is the interaction between Amobarbital and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antifungal response and barbiturate sedation. Adjust fluconazole dose if the response is inadequate.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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