Drug interactions
Amobarbital + Melatonin
Severity: Minor
Amobarbital and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has sedative properties that may add to the hypnotic effect of amobarbital. This can cause greater drowsiness and impaired alertness the next day.
What this interaction means in plain words
Amobarbital and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedative effects from GABAergic barbiturate action and melatonin receptor-mediated sleep promotion.
What to do
Monitor for excess sedation and counsel patients about daytime impairment. Reduce one agent if drowsiness is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Amobarbital with Melatonin?
MediHelp rates the interaction as minor. Amobarbital and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has sedative properties that may add to the hypnotic effect of amobarbital. This can cause greater drowsiness and impaired alertness the next day.
How serious is the interaction between Amobarbital and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel patients about daytime impairment. Reduce one agent if drowsiness is excessive.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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