Drug interactions
Amobarbital + Methamphetamine
Severity: Moderate
Amobarbital and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The stimulant effects of methamphetamine and sedative effects of amobarbital oppose each other, so the response to either may be unpredictable. Sedation may be masked rather than treated, and the cardiovascular strain from the stimulant continues.
What this interaction means in plain words
Amobarbital and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects of CNS stimulation and GABAergic depression; no firmly established pharmacokinetic mechanism.
What to do
Monitor alertness, heart rate and blood pressure, and titrate each drug to clinical effect. Avoid using one to offset the other.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Amobarbital with Methamphetamine?
MediHelp rates the interaction as moderate. Amobarbital and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The stimulant effects of methamphetamine and sedative effects of amobarbital oppose each other, so the response to either may be unpredictable. Sedation may be masked rather than treated, and the cardiovascular strain from the stimulant continues.
How serious is the interaction between Amobarbital and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor alertness, heart rate and blood pressure, and titrate each drug to clinical effect. Avoid using one to offset the other.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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