Drug interactions
Amobarbital + Ondansetron
Severity: Minor
Amobarbital and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower ondansetron concentrations, potentially reducing antiemetic effect. Labeling indicates that enzyme inducers have only a modest effect on ondansetron clearance.
What this interaction means in plain words
Amobarbital and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Induction of CYP3A4 and other hepatic enzymes by amobarbital increases ondansetron clearance.
What to do
No dose change is generally needed; assess antiemetic response and add or switch therapy if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Ondansetron?
MediHelp rates the interaction as minor. Amobarbital and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may lower ondansetron concentrations, potentially reducing antiemetic effect. Labeling indicates that enzyme inducers have only a modest effect on ondansetron clearance.
How serious is the interaction between Amobarbital and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; assess antiemetic response and add or switch therapy if control is inadequate.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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