Drug interactions
Amobarbital + Stiripentol
Severity: Moderate
Amobarbital and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce stiripentol concentrations through enzyme induction, possibly weakening seizure control. Stiripentol in turn inhibits CYP enzymes and may raise barbiturate levels, adding to sedation.
What this interaction means in plain words
Amobarbital and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 and other enzymes increases stiripentol clearance, while stiripentol inhibits barbiturate metabolism.
What to do
Monitor seizure frequency and sedation, and consider measuring drug levels. Adjust the stiripentol or barbiturate dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Amobarbital with Stiripentol?
MediHelp rates the interaction as moderate. Amobarbital and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce stiripentol concentrations through enzyme induction, possibly weakening seizure control. Stiripentol in turn inhibits CYP enzymes and may raise barbiturate levels, adding to sedation.
How serious is the interaction between Amobarbital and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and sedation, and consider measuring drug levels. Adjust the stiripentol or barbiturate dose as needed.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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