Drug interactions
Amoxicillin + Mycophenolate mofetil
Severity: Minor
Amoxicillin and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxicillin, especially with clavulanate, can lower mycophenolic acid trough levels. The effect is usually modest and temporary but could reduce immunosuppression.
What this interaction means in plain words
Amoxicillin and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin belongs to Anti Bacterial; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Altered gut flora may reduce enterohepatic recirculation of mycophenolic acid glucuronide.
What to do
No routine dose change is needed. Monitor for signs of rejection, and consider mycophenolic acid level monitoring during prolonged antibiotic courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Amoxicillin and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amoxicillin, especially with clavulanate, can lower mycophenolic acid trough levels. The effect is usually modest and temporary but could reduce immunosuppression.
How serious is the interaction between Amoxicillin and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for signs of rejection, and consider mycophenolic acid level monitoring during prolonged antibiotic courses.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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