Drug interactions
Amphetamine + Hydrocodone
Severity: Moderate
Amphetamine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release serotonin and norepinephrine, and a serotonin syndrome risk with opioids has been described, though it is uncommon with hydrocodone. Amphetamine may also counter opioid sedation, which can mask the signs of overdose.
What this interaction means in plain words
Amphetamine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphetamine belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Amphetamine-induced monoamine release may add to opioid serotonergic activity; the contribution of hydrocodone is not well established.
What to do
Monitor for agitation, tremor, hyperthermia and autonomic instability, especially at initiation or dose increases. Do not assume that reduced sedation means lower opioid effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphetamine and Hydrocodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Amphetamine
Frequently asked questions
Can I take Amphetamine with Hydrocodone?
MediHelp rates the interaction as moderate. Amphetamine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release serotonin and norepinephrine, and a serotonin syndrome risk with opioids has been described, though it is uncommon with hydrocodone. Amphetamine may also counter opioid sedation, which can mask the signs of overdose.
How serious is the interaction between Amphetamine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and autonomic instability, especially at initiation or dose increases. Do not assume that reduced sedation means lower opioid effect.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
