Drug interactions
Anagrelide + Pentamidine
Severity: Major
Anagrelide and Pentamidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine is associated with QT prolongation and torsades de pointes, and anagrelide may compound this. The combination may precipitate dangerous arrhythmias, particularly with electrolyte disturbances.
What this interaction means in plain words
Anagrelide and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if an alternative is available. If necessary, monitor ECG and correct electrolytes, including magnesium and calcium, during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Anagrelide with Pentamidine?
MediHelp rates the interaction as major. Anagrelide and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is associated with QT prolongation and torsades de pointes, and anagrelide may compound this. The combination may precipitate dangerous arrhythmias, particularly with electrolyte disturbances.
How serious is the interaction between Anagrelide and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available. If necessary, monitor ECG and correct electrolytes, including magnesium and calcium, during treatment.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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