Drug interactions
Anti-thymocyte + Ozanimod
Severity: Major
Anti-thymocyte and Ozanimod: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod reduces circulating lymphocytes and anti-thymocyte globulin depletes T cells, so together they raise the risk of infection. Effects of ozanimod persist for some time after stopping.
What this interaction means in plain words
Anti-thymocyte and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anti-thymocyte belongs to Miscellaneous; Ozanimod belongs to Central Nervous System.
Why it happens
Additive lymphocyte reduction via S1P receptor modulation and T-cell depletion.
What to do
Avoid combining where possible and monitor lymphocyte counts and signs of infection. Allow for washout of ozanimod effects when switching.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anti-thymocyte and Ozanimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Zeposia 0.23 mg hard capsules - SmPC sections 4.3/4.5 (class statement: immunomodulatory or non-corticosteroid immunosuppressive therapies; "Anti-neoplastic, immunomodulatory or non-corticosteroid immunosuppressive therapies should not be coadministered due to the risk of additive immune system eff… — electronic medicines compendium (UK SmPC)
Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Ozanimod?
MediHelp rates the interaction as major. Anti-thymocyte and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod reduces circulating lymphocytes and anti-thymocyte globulin depletes T cells, so together they raise the risk of infection. Effects of ozanimod persist for some time after stopping.
How serious is the interaction between Anti-thymocyte and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and monitor lymphocyte counts and signs of infection. Allow for washout of ozanimod effects when switching.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
