Drug interactions
Apalutamide + Bromocriptine
Severity: Moderate
Apalutamide and Bromocriptine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can lower bromocriptine concentrations, as bromocriptine is mainly cleared by CYP3A4. This may lead to loss of efficacy in Parkinson disease, prolactinoma or acromegaly.
What this interaction means in plain words
Apalutamide and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Bromocriptine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4-mediated metabolism by apalutamide, reducing bromocriptine exposure.
What to do
Monitor clinical response and prolactin or growth hormone and increase the bromocriptine dose if needed. Reassess the dose when apalutamide is stopped, as the induction wears off over weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Bromocriptine?
MediHelp rates the interaction as moderate. Apalutamide and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can lower bromocriptine concentrations, as bromocriptine is mainly cleared by CYP3A4. This may lead to loss of efficacy in Parkinson disease, prolactinoma or acromegaly.
How serious is the interaction between Apalutamide and Bromocriptine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and prolactin or growth hormone and increase the bromocriptine dose if needed. Reassess the dose when apalutamide is stopped, as the induction wears off over weeks.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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