Drug interactions
Apalutamide + Bupropion-naltrexone
Severity: Moderate
Apalutamide and Bupropion-naltrexone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of several metabolic enzymes and may reduce exposure to bupropion and naltrexone. This could reduce weight-management or therapeutic efficacy.
What this interaction means in plain words
Apalutamide and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Bupropion-naltrexone belongs to Miscellaneous.
Why it happens
Apalutamide induces CYP2B6 and UGT enzymes, increasing clearance of bupropion and naltrexone.
What to do
Monitor for loss of efficacy and consider an alternative or dose adjustment within labeled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Bupropion-naltrexone?
MediHelp rates the interaction as moderate. Apalutamide and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of several metabolic enzymes and may reduce exposure to bupropion and naltrexone. This could reduce weight-management or therapeutic efficacy.
How serious is the interaction between Apalutamide and Bupropion-naltrexone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider an alternative or dose adjustment within labeled limits.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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