Drug interactions
Apalutamide + Eliglustat
Severity: Major
Apalutamide and Eliglustat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide can greatly reduce eliglustat exposure, risking loss of control of Gaucher disease. Eliglustat is a CYP2D6 and CYP3A substrate, so induction is clinically relevant.
What this interaction means in plain words
Apalutamide and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Eliglustat belongs to Miscellaneous.
Why it happens
Apalutamide induces CYP3A4, increasing eliglustat clearance.
What to do
Avoid the combination, as eliglustat labeling does not recommend strong CYP3A inducers. Consider alternative therapy for either drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Apalutamide with Eliglustat?
MediHelp rates the interaction as major. Apalutamide and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide can greatly reduce eliglustat exposure, risking loss of control of Gaucher disease. Eliglustat is a CYP2D6 and CYP3A substrate, so induction is clinically relevant.
How serious is the interaction between Apalutamide and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as eliglustat labeling does not recommend strong CYP3A inducers. Consider alternative therapy for either drug.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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