Drug interactions
Apalutamide + Eluxadoline
Severity: Minor
Apalutamide and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is an OATP1B1 substrate, and apalutamide weakly induces this transporter. Reduced exposure of eluxadoline is possible but the clinical relevance is uncertain.
What this interaction means in plain words
Apalutamide and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Apalutamide may weakly induce OATP1B1, altering hepatic uptake and exposure of eluxadoline.
What to do
No dose change is needed. Monitor for reduced control of diarrhea symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Eluxadoline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Apalutamide with Eluxadoline?
MediHelp rates the interaction as minor. Apalutamide and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline is an OATP1B1 substrate, and apalutamide weakly induces this transporter. Reduced exposure of eluxadoline is possible but the clinical relevance is uncertain.
How serious is the interaction between Apalutamide and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for reduced control of diarrhea symptoms.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
