Drug interactions
Apalutamide + Lomitapide
Severity: Moderate
Apalutamide and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce lomitapide exposure because lomitapide is extensively metabolized by CYP3A4. This may lessen LDL cholesterol lowering.
What this interaction means in plain words
Apalutamide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
CYP3A4 induction by apalutamide increases lomitapide clearance.
What to do
Monitor LDL cholesterol and consider titrating lomitapide according to response and liver tests. Consider alternative lipid-lowering therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Apalutamide with Lomitapide?
MediHelp rates the interaction as moderate. Apalutamide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce lomitapide exposure because lomitapide is extensively metabolized by CYP3A4. This may lessen LDL cholesterol lowering.
How serious is the interaction between Apalutamide and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LDL cholesterol and consider titrating lomitapide according to response and liver tests. Consider alternative lipid-lowering therapy if efficacy is lost.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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