Drug interactions
Apalutamide + Lovastatin
Severity: Moderate
Apalutamide and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer, and lovastatin depends heavily on CYP3A4 for first-pass and systemic clearance. Lovastatin exposure may fall substantially, reducing cholesterol-lowering efficacy.
What this interaction means in plain words
Apalutamide and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Lovastatin belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by apalutamide increases the metabolism of lovastatin and lowers its plasma concentrations.
What to do
Monitor the lipid profile after starting apalutamide and consider switching to a statin less dependent on CYP3A4, such as rosuvastatin or pravastatin. Titrate the lovastatin dose to lipid response if it must continue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Lovastatin?
MediHelp rates the interaction as moderate. Apalutamide and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer, and lovastatin depends heavily on CYP3A4 for first-pass and systemic clearance. Lovastatin exposure may fall substantially, reducing cholesterol-lowering efficacy.
How serious is the interaction between Apalutamide and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile after starting apalutamide and consider switching to a statin less dependent on CYP3A4, such as rosuvastatin or pravastatin. Titrate the lovastatin dose to lipid response if it must continue.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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