Drug interactions
Apalutamide + Macimorelin
Severity: Moderate
Apalutamide and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower macimorelin levels, and as it is a diagnostic agent this could produce a falsely abnormal growth hormone stimulation test. The result might be misinterpreted.
What this interaction means in plain words
Apalutamide and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Macimorelin belongs to Endocrine.
Why it happens
CYP3A4 induction by apalutamide increases macimorelin metabolism.
What to do
Consider whether testing can wait until apalutamide has been stopped and its induction has waned, or interpret results with caution.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Apalutamide with Macimorelin?
MediHelp rates the interaction as moderate. Apalutamide and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower macimorelin levels, and as it is a diagnostic agent this could produce a falsely abnormal growth hormone stimulation test. The result might be misinterpreted.
How serious is the interaction between Apalutamide and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider whether testing can wait until apalutamide has been stopped and its induction has waned, or interpret results with caution.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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