Drug interactions
Apalutamide + Nitrofurantoin
Severity: Minor
Apalutamide and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide weakly induces BCRP and could lower exposure to nitrofurantoin if BCRP affects its disposition. Any clinical effect is theoretical and probably small, and nitrofurantoin acts mainly in the urine.
What this interaction means in plain words
Apalutamide and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Weak induction of BCRP transporter by apalutamide, possibly lowering nitrofurantoin exposure.
What to do
No routine adjustment is needed. Watch for reduced antibacterial response if an infection fails to improve.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Nitrofurantoin?
MediHelp rates the interaction as minor. Apalutamide and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide weakly induces BCRP and could lower exposure to nitrofurantoin if BCRP affects its disposition. Any clinical effect is theoretical and probably small, and nitrofurantoin acts mainly in the urine.
How serious is the interaction between Apalutamide and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for reduced antibacterial response if an infection fails to improve.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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