Drug interactions
Apalutamide + Omeprazole
Severity: Moderate
Apalutamide and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C19 and CYP3A4, lowering omeprazole exposure and potentially reducing acid suppression. Loss of efficacy may allow reflux or ulcer symptoms to recur.
What this interaction means in plain words
Apalutamide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Apalutamide induces CYP2C19 and CYP3A4, increasing omeprazole metabolism.
What to do
Monitor for loss of acid suppression and increase the PPI dose if needed, or switch to an agent less dependent on CYP2C19 such as rabeprazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Omeprazole?
MediHelp rates the interaction as moderate. Apalutamide and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C19 and CYP3A4, lowering omeprazole exposure and potentially reducing acid suppression. Loss of efficacy may allow reflux or ulcer symptoms to recur.
How serious is the interaction between Apalutamide and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of acid suppression and increase the PPI dose if needed, or switch to an agent less dependent on CYP2C19 such as rabeprazole.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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