Drug interactions
Apalutamide + Rimegepant
Severity: Moderate
Apalutamide and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may markedly lower rimegepant exposure and reduce migraine efficacy. Rimegepant labeling advises avoiding strong CYP3A inducers.
What this interaction means in plain words
Apalutamide and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Rimegepant belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing rimegepant clearance.
What to do
Avoid rimegepant and use an alternative migraine therapy during apalutamide treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Apalutamide with Rimegepant?
MediHelp rates the interaction as moderate. Apalutamide and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may markedly lower rimegepant exposure and reduce migraine efficacy. Rimegepant labeling advises avoiding strong CYP3A inducers.
How serious is the interaction between Apalutamide and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rimegepant and use an alternative migraine therapy during apalutamide treatment.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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