Drug interactions
Apalutamide + Saxagliptin
Severity: Minor
Apalutamide and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin is metabolized by CYP3A4/5, and apalutamide is a strong CYP3A4 inducer. Saxagliptin exposure may drop, though its active metabolite is formed, so the net loss of effect is likely modest.
What this interaction means in plain words
Apalutamide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Apalutamide induces CYP3A4/5, increasing saxagliptin metabolism.
What to do
Monitor glycemic control and HbA1c, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Saxagliptin?
MediHelp rates the interaction as minor. Apalutamide and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saxagliptin is metabolized by CYP3A4/5, and apalutamide is a strong CYP3A4 inducer. Saxagliptin exposure may drop, though its active metabolite is formed, so the net loss of effect is likely modest.
How serious is the interaction between Apalutamide and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and HbA1c, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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