Drug interactions
Apalutamide + Torsemide
Severity: Minor
Apalutamide and Torsemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C9, which metabolizes torsemide, so torsemide exposure may fall and its diuretic effect may weaken. The effect is expected to be modest and is mainly relevant when diuretic response is critical.
What this interaction means in plain words
Apalutamide and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Torsemide belongs to Cardiovascular.
Why it happens
Apalutamide induction of CYP2C9 increases hepatic clearance of torsemide.
What to do
Monitor for reduced diuretic response such as weight gain or edema, and titrate the torsemide dose upward if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Torsemide
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Torsemide?
MediHelp rates the interaction as minor. Apalutamide and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide induces CYP2C9, which metabolizes torsemide, so torsemide exposure may fall and its diuretic effect may weaken. The effect is expected to be modest and is mainly relevant when diuretic response is critical.
How serious is the interaction between Apalutamide and Torsemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diuretic response such as weight gain or edema, and titrate the torsemide dose upward if needed.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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