Drug interactions
Apalutamide + Trimethoprim
Severity: Minor
Apalutamide and Trimethoprim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim is only partly metabolized by CYP enzymes and is mostly excreted unchanged in urine. A clinically meaningful reduction in its levels from apalutamide is not well established.
What this interaction means in plain words
Apalutamide and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Theoretical minor CYP induction effect on the small metabolized fraction of trimethoprim.
What to do
No routine adjustment is required; assess clinical response to the antibacterial if treatment fails.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Apalutamide with Trimethoprim?
MediHelp rates the interaction as minor. Apalutamide and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethoprim is only partly metabolized by CYP enzymes and is mostly excreted unchanged in urine. A clinically meaningful reduction in its levels from apalutamide is not well established.
How serious is the interaction between Apalutamide and Trimethoprim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; assess clinical response to the antibacterial if treatment fails.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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