Drug interactions
Apixaban + Elagolix
Severity: Moderate
Apixaban and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits P-gp and weakly to moderately induces CYP3A4, so its net effect on apixaban is uncertain. Concentrations could rise or fall, affecting bleeding or clotting risk.
What this interaction means in plain words
Apixaban and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Elagolix belongs to Musculoskeletal.
Why it happens
Opposing effects: P-gp inhibition may raise apixaban levels while CYP3A4 induction may lower them.
What to do
Monitor for both bleeding and thromboembolic events during combined use. Reassess anticoagulation if clinical changes occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Apixaban with Elagolix?
MediHelp rates the interaction as moderate. Apixaban and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix inhibits P-gp and weakly to moderately induces CYP3A4, so its net effect on apixaban is uncertain. Concentrations could rise or fall, affecting bleeding or clotting risk.
How serious is the interaction between Apixaban and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for both bleeding and thromboembolic events during combined use. Reassess anticoagulation if clinical changes occur.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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