Drug interactions
Apixaban + Tucatinib
Severity: Moderate
Apixaban and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-gp and CYP3A4 and may increase apixaban exposure, raising bleeding risk. Patients receiving chemotherapy may already have increased bleeding risk.
What this interaction means in plain words
Apixaban and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 reduces apixaban efflux and metabolism.
What to do
Monitor for bleeding and check blood counts regularly; consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Apixaban with Tucatinib?
MediHelp rates the interaction as moderate. Apixaban and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-gp and CYP3A4 and may increase apixaban exposure, raising bleeding risk. Patients receiving chemotherapy may already have increased bleeding risk.
How serious is the interaction between Apixaban and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check blood counts regularly; consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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